Al Miraj, A K and Chowdhury, Mohammad Rashal and Hossain, Muhammad Kamal and Al – Saad, Md. and Ullah, Mohammad Ata and Kabir, Md. Alamgir (2022) Prevalence and clinical correlates of pulmonary hypertension in systemic sclerosis. European Journal of Biology and Medical Science Research, 10 (3). pp. 1-8. ISSN 2053-406X(Print), 2053-4078(Online)
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Abstract
Development of pulmonary artery hypertension (PAH) worsens prognosis of systemic sclerosis (SSc) and can be either isolated precapillary PAH or secondary to interstitial lung disease (ILD). Early diagnosis is of crucial importance. There is scarcity of data on PAH in patients with SSc in Bangladesh. The objective if the study is to determine the Prevalence and clinical correlates of pulmonary hypertension in systemic sclerosis. Clinical and functional characteristics of 100 patients of systemic sclerosis were studied and they were evaluated by echocardiography to detect pulmonary artery hypertension. Our objective was to study the prevalence and the clinical correlation of PAH in SSc. PAH was found in 29% patients on echocardiography. Prevalence tend to increase with age of onset and duration of disease. However, it did not differ significantly between patients with limited cutaneous SSc (lcSSc) and patients with diffuse cutaneous SSc (dcSSc). On binary logistic regression analysis, none of the studied variables had any independent influence on development of PAH. PAH in SSc occurs in a remarkable proportion (29%) of patients without any ominous signs in early stages. Non-invasive screening of patients with SSc for PAH will help in early diagnosis and appropriate timely therapeutic intervention before significant end-organ damage occurs.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Professor Mark T. Owen |
| Date Deposited: | 19 Apr 2022 07:25 |
| Last Modified: | 19 Apr 2022 07:25 |
| URI: | https://tudr.org/id/eprint/400 |
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