Morris, T. A. and Andreou, E. and Kyriacos, F. and Petrou, C. and Egwim, C.E. (2024) Release of Plant Based Insulin from Kinetics of Dioscorea Dumetorum for the Management of Type 2 Diabetes. International Journal of Dentistry, Diabetes, Endocrinology and Oral Hygiene, 6 (1). pp. 8-29. ISSN 2631-567X,2631-5688
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Abstract
Glucose uptake and growth kinetics with extract fractions of Dioscorea dumetorum was studied employing standard procedures. Pure yeast cell line culture was used to estimate the capability of yeast cell to grow and take up glucose from the system facilitated by extract fractions from food plants. Result shows that kinetics of yeast cell growth with extract fractions at higher rates met up with the healing faster. Some of these extract fractions were very active at very low concentrations compared to standard drug; these can be drug candidates for formulating type 2 diabetes drug that may compete favourable with standard medications which are burdened with side effects and diverse levels of difficulties. The extract fractions being of food plant origin has no likely toxicity and are a natural antioxidant. Kinetic modeling of the extract fractions with yeast cells have suggest a ‘Time-Bound Insulin Releasing System’ (TBIRS) where uptake of glucose was possible at specific given time similar to a intial insulin release kinetics which may lead to prospects for the design of type 2 diabetes medications to support an all-embracing blood glucose control, which is really essential by diabetics in order to reduce the difficulty of drug systems as there is a high probability of the extract fractions effectiveness in the future as drug candidate for type 2 diabetes.
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Professor Mark T. Owen |
| Date Deposited: | 11 Jul 2024 08:49 |
| Last Modified: | 11 Jul 2024 08:49 |
| URI: | https://tudr.org/id/eprint/3175 |
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